PalGD Capsules

Uses and Benefits

PalGD is a synergistic blend designed to support nerve health, cognitive function, and metabolic balance. Key benefits include:

• Palmitoylethanolamide (PEA): Reduces chronic inflammation, alleviates neuropathic pain, and supports nerve health.
• Genistein & Daidzein: Soy isoflavones that promote bone density, balance hormonal health, and act as antioxidants.
• Uridine Monophosphate: Enhances cognitive function, supports synaptic plasticity, and aids brain cell membrane synthesis.
• (6S)-5-Methyltetrahydrofolic Acid: Critical for DNA repair, red blood cell formation, and prenatal health.
• Vitamin B6: Boosts neurotransmitter production, immune function, and amino acid metabolism.
• Vitamin K7 (as MK-7): Strengthens bone health, regulates calcium absorption, and supports cardiovascular function.

Ideal for individuals managing nerve discomfort, cognitive decline, hormonal imbalances, or nutrient deficiencies.

Mechanism of Action

• PEA: Binds to PPAR-α receptors to reduce inflammation and modulate pain signaling.
• Genistein/Daidzein: Mimic estrogen weakly, improving bone density and antioxidant defense via Nrf2 pathways.
• Uridine Monophosphate: Precursor to phosphatidylcholine, enhancing brain cell membrane integrity and neurotransmitter synthesis.
• L-Methyl Folate: Active folate form required for methylation cycles and homocysteine regulation.
• Vitamin B6: Co-factor in serotonin/dopamine synthesis and hemoglobin production.
• Vitamin K7: Activates osteocalcin (bone mineralization) and matrix Gla-protein (prevents vascular calcification).

Contraindications & Cautions

Consult your doctor before use if you:

• Have hormone-sensitive cancers (e.g., breast, prostate) due to isoflavones.
• Are on anticoagulants (Vitamin K7 may interfere with warfarin).
• Have hypercalcemia or kidney stones (Vitamin K7 regulates calcium).
• Are pregnant/breastfeeding (limited safety data on PEA and uridine).

Avoid with:

• SSRIs/MAOIs (Vitamin B6 may alter efficacy).
• Hormone replacement therapies (genistein interactions).

Side Effects

Common side effects (when taken as directed):

• Mild gastrointestinal upset (nausea, bloating).
• Headache or dizziness (Vitamin B6 in high doses).
• Allergic reactions (rash, itching) to soy-derived ingredients.

Severe reactions (seek immediate help):

• Difficulty breathing, chest pain, swelling of face/tongue.

How to Use

• Take 1 capsule daily with food to enhance absorption.
• Swallow whole; do not crush or chew.
• If a dose is missed, take it promptly unless close to the next dose.
• Store at 20–25°C, away from light and moisture. Keep out of children’s reach.

Warnings

• Pregnancy/Lactation: Avoid unless prescribed; genistein and uridine lack safety data.
• Bleeding Disorders: Monitor INR levels if on blood thinners (Vitamin K7).
• Kidney/Liver Issues: High-dose B6 may worsen neuropathy in renal impairment.

Drug Interactions

• Warfarin: Vitamin K7 may reduce anticoagulant efficacy.
• Levodopa: Vitamin B6 may decrease its effectiveness in Parkinson’s treatment.
• Tamoxifen: Genistein may interfere with estrogen receptor modulation.

Composition

Each capsule contains:

• Palmitoylethanolamide (PEA)
• Genistein
• Daidzein
• Uridine Monophosphate
• (6S)-5-Methyltetrahydrofolic Acid
• Vitamin B6 (Pyridoxine HCl)
• Vitamin K7 (MK-7)

Q1. What is PalGD primarily used for?
It targets nerve health, cognitive support, hormonal balance, and bone/cardiovascular wellness.

Q2. Is PalGD suitable for vegetarians?
Yes, if the capsule shell is plant-based and the ingredients are non-animal derived. Confirm via labeling.

Q3. Can I take this with blood thinners?
No. Vitamin K7 may counteract warfarin. Consult your doctor for alternatives.

Q4. How long before I notice improvements?
Nerve pain relief may take 4–6 weeks; cognitive benefits may appear in 8–12 weeks.

Q5. Is it safe for postmenopausal women?
Yes, but consult a doctor if on hormone therapy (genistein may interact).